Epigenetic aspects in pheochromocytoma
10.3760/cma.i.issn.1000-6699.2012.02.001
- VernacularTitle:嗜铬细胞瘤表观遗传学研究现状
- Author:
Chunli FU
;
Zhengpei ZENG
- Publication Type:Journal Article
- Keywords:
Pheochromocytoma;
Epigenetics;
DNA methylation;
MicroRNA
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(2):91-95
- CountryChina
- Language:Chinese
-
Abstract:
Although the mutations in RET,VHL,NF1,SDHB,and SDHD genes have been identified to be responsible for familial pheochromocytomas, the pathogenesis of most pheochromocytomas remains unknown.Inadequate methods to distinguish malignant from benign tumors and a lack of effective treatments for the malignancy are critical problems that require further resolution.Indeed,epigenetic changes are now recognized to be at least as common as genetic changes in cancer.In recent years,research has been initiated to shed light on epigenetic aspects such as DNA methylation and microRNA in pheochromocytomas,to explore the molecular mechanism,and might provide a diagnostic tool and a target for future therapies.
