Relationship between HLA-DRB1 alleles and chronic urticaria with positive autologous serum skin test
10.3760/cma.j.issn.0412-4030.2012.02.002
- VernacularTitle:自体血清皮肤试验阳性慢性荨麻疹与HLA-DRB1基因的相关性研究
- Author:
Yi WU
;
Jinqiu MENG
;
Yulin YAN
;
Cunwei CAO
;
Donghua LIU
;
Ling LIANG
- Publication Type:Journal Article
- Keywords:
Urticaria;
Alleles;
Genes,MHC class Ⅱ;
Skin tests
- From:
Chinese Journal of Dermatology
2012;45(2):78-80
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the relationship between HLA-DRB1 alleles and chronic urticaria with positive autologous serum skin test (ASST) in Guangxi Zhuang Autonomous Region.MethodsASST was conducted in 144 patients with chronic urticaria,who were subsequently divided into two groups according to the test result:positive group (n =62) and negative group (n =82).PCR amplification with sequence-specific primers was used to determine the genotypes of HLA-DRB1 alleles in the patients and 199 normal human controls.Chi-square test was performed to analyse the difference in the frequency of HLA-DRB1 alleles between the 3 groups by using the SPSS 13.0 statistical software package.ResultsThere were significant differences in the frequency of HLA-DRB1*01,*1401 and *16 alleles among the patients with positive and negative ASST and the controls (x2 =10.92,Pc =0.032;x2 =35.34,Pc ＜ 0.01 ;x2 =12.69,Pc =0.032).Paired comparison revealed significant differences in the frequency of HLA-DRB1*1401 allele between the patients with positive ASST and controls(RR =17.09,Pc ＜ 0.01 ) as well as between the patients with positive and negative ASST (RR =7.20,Pc ＜ 0.01).ConclusionHLA-DRB1*1401 allele may be,or be linked to,the predisposing gene of chronic urticaria with positive ASST in Guangxi Zhuang Autonomous Region.
