Expressions of Toll-like receptor 3, 7 and 9 in peripheral blood lymphocytes from patients with pityriasis rosea
10.3760/cma.j.issn.0412-4030.2012.02.022
- VernacularTitle:玫瑰糠疹患者外周血淋巴细胞Toll样受体3、7、9的表达
- Author:
Fan YANG
;
Xiuping HAN
- Publication Type:Journal Article
- From:
Chinese Journal of Dermatology
2012;45(2):130-132
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the roles of Toll-like receptor (TLR) 3,7 and 9 in the pathogenesis of pityriasis rosea.MethodsThis study recruited 40 patients with pityriasis rosea and 40 normal human controls.Reverse transcription-PCR was carried out to detect the expressions of TLR3,7 and 9 in peripheral blood lymphocytes of these subjects.ResultsThe mRNA expressions of TLR3,7 and 9 in peripheral blood lymphocytes were significantly higher in patients with pityriasis rosea than in the normal human controls (Z =4.239,3.745,2.658,all P ＜ 0.05).There was a positive correlation between the expression of TLR3 and TLR7(r =0.574,P ＜ 0.01 ) as well as between that of TLR3 and TLR9 (r =0.551,P ＜ 0.01 ) in the patients,while there was no correlation between TLR7 and TLR9 expression in the patients or between the expressions of TLR3,TLR7 and TLR9 in the controls.ConclusionVirus infection might be involved in the pathogenesis of pityriasis rosea via TLR pathways.
