Macrophage migration inhibitory factor in children with hematologic malignancy complicated with sepsis
10.3760/cma.j.issn.1673-4912.2012.01.020
- VernacularTitle:血液肿瘤患儿合并脓毒症时血清巨噬细胞移动抑制因子的临床意义
- Author:
Liuhong SHI
;
Xiaoqiu WANG
;
Juan QIAN
;
Biru LI
;
Kang AN
;
Ying WANG
- Publication Type:Journal Article
- Keywords:
Spesis;
Macrophage migration inhibitory factor;
Adrenal insufficiency;
Children
- From:
Chinese Pediatric Emergency Medicine
2012;19(1):56-58
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo assess the relationship between serum macrophage migration inhibitory factor (MIF) and sepsis in children with hematologic malignancy.Methods( 1 ) An observational study was performed in a university pediatric intensive care unit.Forty-one children were enrolled in our study,and were divided into two groups:sepsis group (27 cases) and non sepsis group ( 14 cases).(2) Serum samples were taken in the both two groups in 24 h after they were admitted in hospital.Clinical and laboratory parameters,including the levels of serum MIF,cortisol,corticotropin releasing hormone ( CRH),and ferritin were measured and compared between the two groups.Multiple linear regression analysis was used to assess the relationship between MIF and CRH,cortisol and pediatric critical illness score (PCIS).ResultsThe level of MIF was significantly elevated in the sepsis group[ (5 022.71 ± 3 915.82) pg/ml] than that of non sepsis group[ ( 1 722.81 ± 1 738.53) pg/ml] (P =0.001 ).Multiple linear regression analysis showed that CRH as well as PCIS were the correlative factors of MIF( t =- 2.830,P =0.009; t =2.852,P =0.009 ).The higher CRH concentration,the lower PCIS score,and the higher MIF was.ConclusionThe level of serum MIF could reflect the severity of children with hematologic malignancy complicated with sepsis.The higher MIF concentration,the lower PCIS score,then the disease is more serious.To some extent,serum MIF is related with the adrenocortical function of sepsis children.
