Correlation between blood lipids and creatinine clearance in the elderly patients with coronary heart disease
10.3760/cma.j.issn.0254-9026.2012.02.009
- VernacularTitle:老年冠心病患者血脂与肌酐清除率的相关性研究
- Author:
Jie GENG
;
Shutao CHEN
;
Hongliang CONG
;
Lin WANG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Dyslipidemias;
Metabolic clearance rate
- From:
Chinese Journal of Geriatrics
2012;31(2):117-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between blood lipids and creatinine clearance (Ccr)in aged patients with coronary heart disease(CHD).Methods According to coronary artery angiography(CAG)and Ccr,784 subjects aged 65 years and over were divided into groups and Their lipid levels were compared.Results With increasing lesion of coronary branches,the level of Ccr was obviously decreased(F=5.35,P＜0.01).The level of apolipoprotein A1(ApoA1)was reduced and apolipoprotein B(ApoB)enhanced in renal function of moderate-severe injury(CCr＜0.83 ml ·s-1 · 1.73m-2)(F=5.31,F=4.91,both P＜0.01).The level of ApoA1 was decreased(F=3.52,P＜0.05)and Apo B increased(F=5.65,P＜0.01)in male renal function of moderate-severe injury.The levels of ApoA1 decreased(F=5.79,P＜0.01),ApoB increased(F=4.56,P＜0.05)and high density lipoprotein-cholesterol reduced(F=3.39,P＜0.05)in CHD with renal group of moderatesevere injury.Multi-logistic regression analysis showed that Ccr,HDL-C,ApoA1 and ApoB were influencing factors of CHD.Conclusions Abnormal blood lipid and renal dysfunction are risk factors of CHD,dyslipidemia may induce renal dysfunction.It is important to control lipids and improve other organ functions in the aged patients with CHD.
