Impacts of bone marrow stem cells autologous transplantation after acute myocardial infarction on local mRNA expression of SDF-1, Kit ligand, E-selectin, ICAM-1 and VCAM-1
10.3760/cma.j.issn.1008-1372.2012.01.016
- VernacularTitle:骨髓单个核细胞移植后心肌梗死区细胞因子mRNA表达的实验研究
- Author:
Jianping ZENG
;
He HUANG
;
Zhishan SUN
;
Xiaojun TAN
;
Hui LI
;
Ping LIU
- Publication Type:Journal Article
- Keywords:
Bone marrow transplantation;
Myocardial infarction/ME;
Stem cell factor/ME;
Chemokine CXCL12/ME;
E-selectin/ME;
Intercellular adhesion molecule-1/ME;
Cell adhesion molecules/ME
- From:
Journal of Chinese Physician
2012;14(1):54-57
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of bone marrow stem cells autologous transplantation after acute myocardial infarction on local mRNA expression of SDF-1,Kit ligand,E-selectin,ICAM-1and VCAM-1.Methods Acute myocardial infarction models were established in 10 swine,which were randomized divided into placebo group (5 swine) and transplantation group (5 swine).After six months,hearts of placebo group and early transplantation group were harvested and mRNA expression of SDF-1,Kit ligand,E-selectin,ICAM-1 and VCAM-1 in infarcted myocardial region was detected.Results The mRNAs of SDF-1,Kit ligand,E-selection,ICAM-1 and VCAM-1 were expressed in the infarcted myocardial region of transplantation group six months after myocardial infarction,but it was not found in the placebo group.ConclusionsBone marrow autologous transplantation after acute myocardial infarction can promote local mRNA expression of SDF-1,Kit ligand,E-selectin,ICAM-1 and VCAM-1,which may be due to the paracrine effects of stem cells.
