Comparison of response evaluation criteria in solid tumors (RECIST), European Association for the study of the liver (EASL) and modified RECIST criteria in evaluation of tumor response after transarteriai chemoembolization of primary liver cancer
10.3760/cma.j.issn.1005-1201.2011.08.014
- VernacularTitle:实体瘤反应评价标准、欧洲肝病学会和改良实体瘤反应评价标准评价原发性肝癌化疗栓塞效果一致性的比较
- Author:
Wenchang YU
;
Kongzhi ZHANG
;
Shiguang CHEN
;
Hailan LIN
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Chemoembolization,therapeutic;
Evaluation studies
- From:
Chinese Journal of Radiology
2011;45(8):766-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the concordance among RECIST, EASL and modified RECIST criteria for the evaluation of tumor response after transarterial chemoembolization of primary liver cancer.Methods Fifty patients with primary liver cancer underwent 2 TACE cycles separated by 30-40 days.Triphasic helical CT or MRI scans were performed at baseline, at 4 weeks after TACE procedure, and 2 independent radiologists evaluated tumor response according to above-mentioned three different criteria. Chisquare test was used to compare the response rate, and kappa coefficients were used to evaluate the coherence. Results When tumor responses were evaluated using the RECIST-EASL and modified RECIST criteria, the numbers of the patients achieved complete response, partial response, stable disease,progressive disease were 0, 10, 30, 10; 6,21,14,9; 6,21,13,10 respectively. The objective response rates for three different criteria were 20%, 54%, 54% respectively ( P ＜ 0. 01 ). Kappa coefficients between RECIST and EASL, between RECIST and modified RECIST, between EASL and modified RECIST were 0. 382, 0. 170, and 0. 857 (P = 0. 000). Conclusions RECIST criteria underestimates the extent of tumor response after TACE in primary liver cancer. Both EASL and modified RECIST criteria appear to agree with each other in determining treatment response. Furthermore, the modified RECIST is more convenient in clinical practice compared with EASL criteria.
