Relationship between obstructive sleep apnea-hypopnea syndrome and metabolic syndrome in obese middle-aged and older men
10.3760/cma.j.issn.0254-9026.2011.08.001
- VernacularTitle:中老年男性肥胖者阻塞性睡眠呼吸暂停低通气综合征与代谢综合征相关性研究
- Author:
Qichang LIN
;
Xiaobin ZHANG
;
Chaosheng DENG
;
Zhiming CAI
;
Lingyan SHI
;
Hua CHEN
- Publication Type:Journal Article
- Keywords:
Sleep apnea syndrome;
Obesity;
Metabolic syndrome
- From:
Chinese Journal of Geriatrics
2011;30(8):617-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between obstructive sleep apnea-hypopnea syndrome (OSAHS) and metabolic syndrome (MS) in obese middle-aged and older men. Methods We selectively recruited 154 obese middle-aged and older men matched for body mass index (BMI) and age. The polysomnography was performed for diagnosing OSAHS and for discriminating disease severity. The BMI, waist circumference, blood pressure, plasma glucose and lipid profiles were measured and analyzed in all subjects. Appropriate statistical methods were used to compare the components of MS in each group. Logistic regression was taken to elucidate the relationship between OSAHS and MS. Results Compared to control group, severe OSAHS group had significantly lower high density lipoprotein cholesterol level [( 1.03 ± 0.29 ) mmol/L vs. ( 1.31 ± 0. 38) mmol/L,P＜0. 05] and higher fasting glucose [(6.61±1.76) mmol/L vs. (5.47±0.64) mmol/L, P＜0. 05]as well as higher systolic blood pressure [( 133 ± 13) mm Hg vs. ( 125 ± 12) mm Hg, P＜0. 05] and diastolic blood pressure [(99±10) mm Hg vs. (80±5) mm Hg, P＜0. 05]. The prevalence of MS was significantly higher in OSAHS group than in control group (mild OSAHS group: 25.7%,moderate OSAHS group: 46. 5%, severe OSAHS group: 84.4%, control group: 16. 1 %, all P＜0. 01). OSAHS was independently associated with an increased prevalence of MS Odds ratio, 6.16).Conclusions OSAHS is independently associated with MS in obese middle-aged and older men.
