Observation of postoperative analgesic effects of intravenous parecoxib in gerontal patients undergoing laparoscopic cholecystectomy
10.3760/cma.j.issn.0254-9026.2011.08.011
- VernacularTitle:帕瑞昔布用于老年患者腹腔镜胆囊切除术后镇痛效果观察
- Author:
Hongye ZHANG
;
Mingzhang ZUO
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase inhibitors;
Analgesia;
Cholecystectomy,laparoscopy
- From:
Chinese Journal of Geriatrics
2011;30(8):654-656
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the postoperative analgesic effects of perioperative intravenous parecoxib in gerontal patients undergoing laparoscopic cholecystectomy. Methods A prospective,randomized, double-blind, placebo-controlled, parallel group study was performed. The 40 American Society of Anesthesiologists (ASA) Ⅰ or Ⅱ patients (aged 60-80 years) undergoing elective laparoscopic cholecystectomy under general anesthesia were randomly allocated to 2 groups (n = 20,each): the parecoxib group received intravenous parecoxib 40 mg at 10 minutes before incision and 12 hours and 24 hours after incision; however, the placebo group received 5 ml normal saline instead of parecoxib at the same time. The intensity of algesia was measured using visual analogue scale (VAS)scores (1-10, 0 = no pain, 10 = worst pain), and was recorded at 2, 4, 6, 12, 24 hours after operation. The patients' global evaluation of postoperative analgesia was recorded and compared between the two groups. Results The VAS scores at the different time points were significantly less in parecoxib group than in placebo group (all P＜ 0.05). The patients' global evaluation of postoperative analgesia was higher in parecoxib group than in placebo group [(8. 1 ± 1.2) scores vs.(5.2± 0. 9 ) scores, t = 7. 402, P ＜ 0. 05]. Conclusions Intravenous parecoxib can effectively relieve postoperative algesia and improve postoperative analgesia after laparoscopic cholecystectomy.
