Antidepressant Effects of Ethaverine, a Calcium Channel Antagonist, in Animal Models of Depression.
- Author:
Sang Kyeong LEE
1
;
Sun Hee KIM
;
Luck Woo KIM
;
Sung Hwan YOON
;
Yong Kwan KIM
;
Kyong Tai KIM
;
Young Hoon KIM
Author Information
1. Department of Neuropsychiatry, School of Medicine, and Institute of Neuroscience, Inje University, Pusan Paik Hospital, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Ethaverine;
Calcium channel antagonist;
Forced swimming test;
Chronic mild stress;
Depression
- MeSH:
Animals*;
Calcium Channels*;
Calcium*;
Depression*;
Imipramine;
Models, Animal*;
Physical Exertion;
Rats;
Sucrose
- From:Journal of Korean Neuropsychiatric Association
2000;39(2):445-455
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This pre-clinical study was performed to assess the effects of ethaverine in the two kinds of behavioral models of depression in rats. METHODS: We observed the changes of the immobility time in the forced swimming test and the quantity of sucrose consumed in the chronic mild stress model, using ethaverine(20mg/kg) alone, imipramine(20mg/kg) alone, or ethaverine and imipramine concomitantly. RESULTS: In the forced swimming test, both single treatment and chronic treatment(for 7 days) with imipramine or ethaverine significantly reduced the immobility time, and concomitant chronic treatment with ethaverine potentiated the effect of imipramine. In the chronic mild stress model, both imipramine and ethaverine reversed the decreased sucrose consumption induced by 3-week stress and concomitantly treated ethaverine potentiated the effect of imipramine in the early phase of treatment. CONCLUSIONS: The data suggest that ethaverine can be used alone or concomitantly with other anti-depressants in the clinical situation.
