Efficacy of solifenacin with or without tamsulosin in patients with overactive bladder

VernacularTitle:索利那新加坦索罗辛治疗膀胱过度活动症的疗效分析
Author: Zhilu FAN ; Hongwei JU ; Chuangang LI ; Xudong JIANG ; Zhiyu LIU ; Sixiong JIANG ; Yang YU ; Weiwei FAN ; Yaohua SHANG
Publication Type:Journal Article
Keywords: Solifenacin; Tamsulosin; Overactive bladder
From: Chinese Journal of Urology 2011;32(8):532-534
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy of solifenacin with or without tamsulosin in patients with overactive bladder (OAB).Methods Fifty-three patients with OAB were randomly divided into two groups (group A 27 patients, group B 26 patients).The patients received either solifenacin 5 mg/day in group A or combined with Tamsulosin 0.2 mg/day in group B for two weeks.During the treatent period all the patients recorded voiding and adverse events in a diary.The symptoms of urgency, frequency, incontinence were evaluated by OABSS scores at the begining and end of the therapy period.The results of the efficacy and safety were analyzed by using SPSS 13.0.Results The OABSS scores at the begining and end for the two groups were significantly different ( P ＜ 0.01 ).In both groups the efficacy was obvious.The OABSS scores at the end of the therapy between group A and B were significantly different (P ＜0.05 ).The efficacy of group B was better than that of group A.Conclusion The efficacy of solifenacin combined with tamsulosin was better than solifenacin alone in OAB.