Treatment of idiopathic hypogonadotropic hypogonadism with pulse infusion of gonadorelin via micro pump
10.3760/cma.j.issn.1000-6699.2011.08.011
- VernacularTitle:微量泵脉冲输注戈那瑞林治疗特发性低促性腺激素性性腺功能减退症
- Author:
Shouyue SUN
;
Weiqing WANG
;
Yiran JIANG
;
Yifeng WANG
;
Junna YE
;
Manna ZHANG
;
Wei ZHOU
;
Weiwei ZHAN
;
Xiaoying LI
;
Guang NING
- Publication Type:Journal Article
- Keywords:
Hypogonadism;
Gonadorelin;
Infusion pumps
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(8):654-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of pulse infusion of gonadorelin (LHRH) on the patients with idiopathic hypogonadotropic hypogonadism (IHH) via a micro infusion pump. Methods The protocol was designed as an open, self-controlled prospective study. 31 patients were enrolled and assigned to 3 groups: 23 males without gonadotropin-releasing hormone ( GnRH ) pulse ( group A), 2 males with GnRH pulse frequency insufficiency ( group B), and 6 females ( group C). All the subjects were admitted LHRH every 90 min via the micro infusion pump for 24 weeks. Sex hormones and related characteristics were compared before and after the treatment. Results After 24-weeks treatment, LH peak value reached ( 6. 92 ±5.66 ), ( 9. 55 ±0. 98 ), and ( 6. 93 ±4. 52 ) IU/L; and FSH peak value reached ( 7.44 ± 3. 80 ), ( 12. 85 ± 12. 80 ), and ( 7.38 ±4. 98 ) IU/L among 3 groups, respectively. The testosterone also reached ( 3.18± 1.81 ) and ( 5.78±4. 65 ) ng/ml in groups A and B ( all P＜0. 01 ). In groups A and B, the testis volumes were increased, seminal fluid production was found in 7 patients and spermatogenesis in 6 patients. In group C, uterus was enlarged 85.4%, as well as the ovaries of both sides. Menarche was reported in 5 patients. 19. 4% of the studied patients complained uncomfortable at the injection sites, all the symptoms were mild. Conclusion Pulse infusion of LHRH in IHH patients via a micro infusion pump is effective, while the medication system needs improving.
