Relationship between liver X receptor (LXR) expression and hepatic glucose metabolism in the insulin resistant obese rats
10.3760/cma.j.issn.1000-6699.2011.08.017
- VernacularTitle:肝X受体表达与胰岛素抵抗肥胖大鼠的肝糖代谢相关
- Author:
Dong YING
;
Liu WEI
- Publication Type:Journal Article
- Keywords:
Liver X receptor;
11 β-hydroxysteriod dehydrogenase 1;
Obesity;
Insulin resistance
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(8):677-679
- CountryChina
- Language:Chinese
-
Abstract:
Twenty-seven male SD rats were assigned to 3 groups: control, obese, and obese with diabetes groups. Serum corticosterone was determined and euglycemic-hyperinsulinemic clamp was carried out. Expressions of liver X receptor ( LXR), 11 β-hydroxysteroid dehydrogenase 1 ( 11 β-HSD1 ), and glucocorticoid receptor (GR) were determined by real-time PCR. Both groups of obese rats were insulin-resistant, with up-regulated LXR mRNA and down-regulated 11 β-HSD1 mRNA( both P＜0.05 ).
