Therapeatic effects of two different dosage of rosuvastatin on endothelial dysfunction in diabetic rats
10.3760/cma.j.issn.0254-9026.2011.08.022
- VernacularTitle:瑞舒伐他汀改善糖尿病大鼠血管内皮功能的实验研究
- Author:
Peiyi XIE
;
Zhijie ZHANG
;
Yousu SU
;
Wen AI
;
Fei CHEN
;
Lei WANG
;
Shaoyuan CHEN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Endothelium,vascular;
Nitric oxide
- From:
Chinese Journal of Geriatrics
2011;30(8):687-689
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of two different dosage of rosuvastatin on endothelial dysfunction in diabetic rats. Methods The 24 diabetic rats were randomly divided into three groups (n=8,each): diabetic control group, 20 mg rosuvastatin daily (RV 20 mg group) and 10mg rosuvastatin daily for 8 weeks (RV 10 mg group) and normal control group (SD group). The levels of blood glucose, lipid, nitric oxide(NO) and endothelin-1 (ET-1) were measured before and 8 weeks after treatment. Results The levels of blood glucose were higher in all diabetic rats groups than in SD group before experiment (P＜0. 01). Compared with diabetic rats control group, blood glucose was slightly lower in RV 10 mg group and RV 20 mg group at 8 weeks (P＞0. 05). The plasma NO level was significantly lower in diabetic rats control group than in SD group (P＜0. 05).After 8 weeks, plasma NO levels were significantly higher in RV 20 mg and RV 10 mg groups than in diabetic rats control group (P＜0. 01 or P＜0. 05). The plasma levels of ET-1 was significantly higher in diabetic rats control group than in SD group (P＜0. 01). After 8 weeks, plasma ET-1 levels were significantly lower in RV 20 mg and RV 10 mg group than in diabetic rats control group (P＜0. 01).Meanwhile, the plasma lipids were lower in RV 20 mg and RV 10 mg group than in diabetic control group (P＜0. 05 or P＜0. 01). Conclusions Rosuvastatin can adjust blood lipids and significantly improve endothelial function in diabetic rats by increasing plasma NO level and decreasing plasma ET-1 level.
