The Serum Levels of Interleukin-8, Monocyte Chemoattractant Protein-1, and Macrophage Inflammatory Protein-1 alpha in Patients with Acute Ischemic Stroke and with Atherosclerosis.
- Author:
Jae Kwan CHA
1
;
Sang Ho KIM
;
Jae Woo KIM
Author Information
1. Department of Neurology, College of Medicine, Dong-A University.
- Publication Type:Original Article
- Keywords:
Chemokines;
Stroke;
Atherosclerosis;
Cytokines
- MeSH:
Arteries;
Atherosclerosis*;
Carotid Artery Diseases;
Chemokine CCL2*;
Chemokines;
Chemokines, CC;
Cytokines;
Enzyme-Linked Immunosorbent Assay;
Humans;
Interleukin-8*;
Interleukins;
Leukocytes;
Lymphocytes;
Macrophage Inflammatory Proteins*;
Macrophages*;
Monocytes*;
Prospective Studies;
Stroke*;
Vascular Diseases
- From:Journal of the Korean Neurological Association
2000;18(2):132-137
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Chemokines are molecules with chemotatic activities on selective leukocyte populations and are sub-grouped into alpha-chemokine acting primarily on PMNL (polymorphonuclear leukocyte) and beta-chemokines attracting mainly lymphocytes and monocytes. We conducted a prospective study to investigate the serum levels of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1 alpha in patients with acute ischemic stroke and carotid atherosclerosis. METHODS: Serum was sampled from patients with acute ischemic stroke (<24hrs), with persistent ischemic neurological deficits associated with atherosclerosis (>1 month), and from normal subjects without a history of vascular disease. Concentrations of chemokines were measured by enzyme linked immunosorbent assay ( ELISA ). RESULTS: Compared with carotid atherosclerotic patients and control subjects, the serum levels of IL-8 were significantly elevated in those with acute ischemic stroke. The serum levels of MCP-1 in patients with large artery disease were higher than those in patients with small vessel disease and cardioembolism. CONCLUSIONS: This study suggested that IL-8 can be involved in acute ischemic stroke and MCP-1 plays a role in the pathogenesis of atherosclerosis.
