Relationship between gastric cancer and glutathione S-transferase P1 gene polymorphism in the elderly

VernacularTitle:老年人胃癌与谷胱甘肽转硫酶P1基因多态性关系的研究
Author: Yuelong JIANG ; Xiaoquan ZHU ; Le XU
Publication Type:Journal Article
Keywords: Stomach neoplasms; Glutathione s-transferase P1; Helicobacter,pylori
From: Chinese Journal of Geriatrics 2011;30(8):651-653
CountryChina
Language:Chinese
Abstract: Objective To study the relationships of Helicobacter pylori (Hp) infection and genetic polymorphisms of glutathione s-transferase P1 (GSTP1) with gastric cancer (GC). Methods The 98 patients with GC and 149 controls with normal finding at endoscopy were enrolled for this study. The rapid urease test (RUT), 13C- urea breath test (13C-UBT) and Giemsa staining of biopsy samples were used to check Hp infection. PCR-based restriction fragment length polymorphisms (PCR-RFLP) was used to detect GSTP1 genotype. Results The rate of Hp infection was higher in GC group than in control group (54.1% vs. 40.9%, x2 =4.11, P＜0. 05). The risk of GC would significantly increase in the GSTP1 homozygous mutant gene (MM) group with Hp infection (OR=5.44, 95%CI 1. 26-26. 79, x2=7.13, P＜0.05). Conclusions Hp infection and GSTP1 genetic polymorphisms are associated with gastric cancer risk in the elderly.