Clinical observation of the improvement of left ventricular function by phosphocreatine in elderly patients with chronic heart failure
10.3760/cma.j.issn.0254-9026.2011.08.007
- VernacularTitle:磷酸肌酸钠改善老年慢性心力衰竭患者左心功能的观察
- Author:
Songtao AN
;
Lixia WANG
;
Yanyan QI
;
Bingyu QIN
;
Yongqiang LI
- Publication Type:Journal Article
- Keywords:
Phosphocreatine;
Heart failure,congestive;
Natriuretic peptide,brain
- From:
Chinese Journal of Geriatrics
2011;30(8):640-642
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effects of phosphocreatine treatment on left ventricular function and on amino-terminal pro-brain natriuretic peptide (NT-proBNP) level in elderly patients with chronic heart failure. Methods In our department, the 172 elderly patients with chronic heart failure were randomly divided into treatment group and control group (n= 86, each).The control group received routine anti-heart failure treatment. The treatment group received conventional therapy plus creatine phosphate sodium for 4 weeks. The cardiac function was evaluated and the NT-proBNP level was measured in all subjects. Results Four weeks after treatment, the improvements of left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic dimension (LVEDD) were better in treatment group than in control group (all P＜0.05). The plasma NT-proBNP level decreased significantly in treatment group as compared with control group [before treatment: (956.4 ± 644.2) pmol/L and (973.6 ±639.8) pmol/L; after treatment: (414. 5 ± 163.8 ) pmol/L and ( 719.3 ± 477. 5 ) pmol/L, all P＜0. 05]. Conclusions Phosphocreatine could improve left ventricular function and decrease plasma NT-proBNP level in elderly patients with chronic heart failure.
