Effects of solifenacin on overactive bladder patients

Jianguo Wen; Yan Chen; Jinsheng LI; Ruili Zhang; Qingjun Meng; Rui Wang; Baoping Qiao; Jinxing Wei; Weixing Zhang

Return

Effects of solifenacin on overactive bladder patients

VernacularTitle:索利那新治疗膀胱过度活动症对逼尿肌功能的影响
Author: Jianguo WEN ; Yan CHEN ; Jinsheng LI ; Ruili ZHANG ; Qingjun MENG ; Rui WANG ; Baoping QIAO ; Jinxing WEI ; Weixing ZHANG
Publication Type:Journal Article
Keywords: Solifenacin; Overactive bladder; Detrusor; Urodynamics
From: Chinese Journal of Urology 2011;32(8):528-531
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of solifenacin on the detrusor instability of patients with overactive bladder (OAB).Methods A total of 20 outpatients with OAB of.1 - 20 ( mean, 8 )years, 12 males and 8 females, aged 21 - 83 ( mean, 43) years were included in this study.Five mg solifenacin was given orally once daily for 12 weeks.Before and after treatment, overactive bladder symptom score (OABSS), patient perception of bladder condition symptoms rating scale (PPBC), and filling cystometry was performed.Results Before and after solifenacin administration, significant decrease were detected in term of unstable detrusor waves ( 2.3 ± 2.4) vs (0.6 ± 1.3 ) ( P ＜ 0.05 ), and detrusor overactivity ( DO ) disappeared in 6 patients.Bladder capacities at first desire to void and maximum bladder capacity were significantly increased (P ＜0.01 ).Bladder compliance and detrusor pressure at maximum urine flow had no significant difference (P ＞ 0.05 ).All patients had significant improvement in OAB symptoms evaluating by OABSS and PPBC ( P ＜ 0.05 ).Six patients had mild side effect of dry mouth and could be relieved by drinking more water.Conclusion Urodynamically, solifenacin decreases the detrusor overactivity, increases the bladder capacity and improves the quality of life of OAB patients.