Association of angiopoietins and soluble angiopoietin receptor Tie-2 with diabetic retinopathy in patients with type 2 diabetes
10.3760/cma.j.issn.1000-6699.2011.08.006
- VernacularTitle:血管生成素及其Tie-2受体与2型糖尿病视网膜病变的相关性研究
- Author:
Qiaoying YOU
;
Qiqian ZHU
;
Xuwei SI
;
Xingmu WANG
- Publication Type:Journal Article
- Keywords:
Angiopoietin;
Receptor Tie-2;
Diabetes mellitus,type 2;
Retinopathy
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(8):639-641
- CountryChina
- Language:Chinese
-
Abstract:
Angiopoietin-2 levels were 5. 80 ( 3. 83-8. 00 ) , 4. 42 ( 2. 56-5. 55 ) , and 2. 75 ( l. 40-4. 64 )ng/ml in type 2 diabetic patients with proliferative retinopathy, patients with non-proliferative retinopathy, and patients without retinopathy, respectively. Statistical significances existed between any two groups (all P ＜0. 01 ). Angiopoietin-1 level in patients with non-proliferative retinopathy was higher than that in patients without retinopathy [10. 57 ( 8. 99-12. 05 ) vs 9. 21 (7. 71-11.2 ) ng/ml, P＜0. 05]. No difference in receptor Tie-2 was found among the 3 groups (P＞0. 05 ). The results suggested that serum angiopoietin-2 level might be associated with the severity of retinopathy in type 2 diabetic patients.
