Clinicopathological analysis of HBV recurrence in post-liver transplantation patients
10.3760/cma.j.issn.0254-1785.2011.08.008
- VernacularTitle:肝移植后乙型病毒性肝炎复发的临床病理研究
- Author:
Yinjie GAO
;
Hanwei LI
;
Jingmin ZHAO
;
Min ZHANG
;
Bo JIN
;
Fanping MENG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Hepatitis B;
Recurrence;
Pathology
- From:
Chinese Journal of Organ Transplantation
2011;32(8):477-480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological characteristics of HBV recurrence after liver transplantation. Methods The retrospective analysis of the clinicopathological changes was performed on 17 patients who had HBV recurrence after liver transplantation in our medical department. Results HBV recurrence happened from 4 to 48 months. Twelve of them which were identified to be YMDD mutation switched to entecavir or added adefovir. Three of them receiving chemotherapy when liver cancer recurred switched to entecavir. Two of them with withdrawal of lamivudine were given lamivudine continuously. Liver function returned to the normal level and HBVDNA was ＜ 102 U/ml after anti-hepatitis B virus. The histological changes in the transplanted livers included hepatocellular degeneration, necrosis and apoptosis, portal infiltrations and fibrosis.With time after recurrence, it was easier to see hepatitis B virus replication in liver cells, incidence of acute rejection, increases of liver fibrosis and the formation of fibrous septa, even pseudolobule.Conclusion In native HBV infection livers, fibrosis occurs more early and develops rapidly. The number of virus is closely related to liver necrosis and inflammation. Early discovery and change to quick and effective treatment of anti-hepatitis B virus in time can improve greatly the prognosis of the patients.
