The effect of polygonum perfoliatum L on HIF-1αand VEGF of hepatic tissue of hepatic fibrosis rats
10.3760/cma.j.issn.1008-1372.2011.07.020
- VernacularTitle:扛板归对肝纤维化大鼠肝组织缺氧诱导因子1α及血管内皮生长因子表达的影响
- Author:
Qingsheng CAO
;
Zhichao LI
;
Bo BAI
;
Guangyu CHEN
;
Baoyou YANG
- Publication Type:Journal Article
- Keywords:
POLYGONUM PERFOLIATUM /PD;
Liver cirrhosis/ZD/ME;
Hypoxia-inducible factor 1/ME;
Vascular endothelial growth factors/ME;
Liver/ME
- From:
Journal of Chinese Physician
2011;13(7):935-937
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of polygonum peffoliatum L on the expression of Hypoxia inducible factor-1 (HIF-1α) and vascular endothelia growth factor (VEGF) in hepatic fibrosis rats induced by Dimethylnitrosamine (DMN) . Methods Seventy-two SD rats were randomly divided into six groups, after the model of HF rat induced by DMN and intervened by different concentrations of Polygonum perfoliatum L. Conventional flaking of liver and HE were used to observed histopathological change. Immunohistochemstry was used to detect HIF-1αand VEGF in hepatic tissues of hepatic fibrosis rats. Results The expression of HIF-1α and VEGF in hepatic fibrosis rats of the high dose of Polygonum perfoliatum L from (-) to (3 +) were one , nine, one, zero and one, eight, two, zero, respectively. The expression of HIF-1α and VEGF in hepatic fibrosis rats of the middle dose of Polygonum perfoliatum L from (-) to (3 +)were one , seven, two, zero and one, six, three, zero, respectively. Compared with the model group, the high and middle dose of Polygonum perfoliatum L can reduce the expression of HIF-1 oand VEGF in hepatic fibrosis rats (P ＜ 0. 01). Conclusions Polygonum peffoliatum L has a good curative effect of anti hepatic fibrosis. Its therapeutic mechanism mainly maybe due to adjust the metabolism of extracellular matrix by decreasing HIF-1 αand VEGF expression.
