Genetic polymorphism of HIF-1α G1790A associated with radiosensitivity of nasopharyngeal carcinoma

VernacularTitle:HIF-1α基因多态性与鼻咽癌放疗敏感性的相关性研究
Author: Zhichao FU ; Huihua CHENG ; Dongshi LI ; Fengmei WANG ; Guishan LIN
Publication Type:Journal Article
Keywords: H ypoxia inducible factor 1 α; Single nucleotidepolymorphism; Nasopharyngeal carcinoma; Radiosensitivity
From: Chinese Journal of Radiological Medicine and Protection 2011;31(4):430-432
CountryChina
Language:Chinese
Abstract: Objective To explore the association between the genetic polymorphism of hypoxia inducible factor 1 α (HIF-1α) G1790A and the radiosensitivity of nasopharyngeal carcinoma.Methods A total of 189 patients with nasopharyngeal carcinoma treated with radical radiotherapy were followed-up for 3 years.The patients were divided into cured group with 135 cases and recurrence group with 54 cases by clinical follow-up results.PCR-RFLP was used to determine the mononucleotide genotypes of HIF-1α G1790A.Results The observed genotype frequencies of HIF-1α gene 1790 (G→A) for GG, GA and AA were 70.04% , 20.74% , 2.22% in cured group and 59.26% , 38.89% , 1.85% in recurrence group, respectively.The allele frequencies for G and A were 87.4% , 13.9% in cured groups and 78.7% ,21.3% in recurrence group, respectively, without significant difference in distribution of allele frequencies between the two groups(x2 =6.919, P =0.077).Conclusions The genetic polymorphisms of HIF-1α G1790A might be related with the radiosensitivity of nasopharyngeal carcinoma.