Effect of diabetes mellitus on neuromuscular blocking effect of cisatracurium
10.3760/cma.j.issn.0254-1416.2011.06.006
- VernacularTitle:糖尿病因素对患者顺阿曲库铵肌松效应的影响
- Author:
Jinfeng LI
;
Gaoqi YU
;
Tongwei YANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Atracurium;
Neuromuscular blockade
- From:
Chinese Journal of Anesthesiology
2011;31(6):671-673
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of diabetes mellitus on neuromuscular blocking effect of cisatracurium in patients. Methods Forty ASA Ⅱ patients, aged 30-64 yr, weighing 44-90 kg, scheduled for neurosurgical operation under general anesthesia, were assigned into 2 groups (n = 20 each): type 2 diabetes mellitus group (group D) and non-diabetes mellitus group (group ND). General anesthesia was induced with midazolam,fentanyl and etomidate. Neuromuscular block was assessed with Epoch XP nerve electrophysiology monitor. A train-of-four stimulation of ulnar nerve was used. Cisatracurium 0.15 mg/kg was injected intravenously over 5 s after T1 was maintained at 100%. Tracheal intubation was performed after the onset of the muscle relaxant. Anesthesia was maintained with iv infusion of propofol 4-8 mg· kg - 1 · h - 1 and remifentanil 0.1-0.3μg· kg - 1 · min - 1. The effect of inmbation was evaluated and graded. The onset time, clinical duration, recovery time and recovery index were recorded. Results The onset time was significantly longer in group D than in group ND ( P ＜ 0.05). There was no significant difference in the clinical duration, recovery time and recovery index and intubation effect grade between the two groups ( P ＞ 0.05). Conclusion Diabetes can prolong the onset time of cisatracurium, but has no effect on the clinical duration and recovery time.
