Diffusion-weighted Magnetic Resonance Image Findings in Clinically Diagnosed Creutzfeldt-Jakob Disease.
- Author:
Seung Han LEE
1
;
Byeong Chae KIM
;
Sung Min CHOI
;
Yong Seok YANG
;
Myeong Kyu KIM
;
Jeong Jin SEO
;
Ki Hyun CHO
Author Information
1. Department of Neurology, Chonnam University Medical School.
- Publication Type:Original Article
- Keywords:
Creutzfeldt-Jakob disease;
Diffusion-weighted MRI;
Basal ganglia hyperintensity
- MeSH:
Aged;
Ataxia;
Basal Ganglia;
Cerebral Cortex;
Creutzfeldt-Jakob Syndrome*;
Dementia;
Diagnosis;
Electroencephalography;
Hand;
Humans;
Myoclonus
- From:Journal of the Korean Neurological Association
2000;18(2):219-223
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report distinctive diffusion-weighted magnetic resonance image (DWI) findings in a 65-year-old man with clinically diagnosed Creutzfeldt-Jakob disease (CJD). Four weeks before admission he developed general weakness and febrile sense which were followed by progressive dementia, ataxia, and choreo-athetoid movement of the right hand. T2-weighted magnetic resonance image (MRI) showed subtle high signal intensities only in the left basal ganglia, whereas DWI demonstrated marked hyperintensities in multiple regions including the left basal ganglia and left cerebral cortex. Five weeks after the onset of symptoms, he was noted to have myoclonus and characteristic electroencephalographic changes consisting of periodic triphasic sharp waves. In our patient, high signal changes on the DWI preceded myoclonus and typical EEG findings, a result suggesting that DWI may be useful in the early premortem diagnosis of CJD.
