The management of patent ductus arteriosus in premature infants
10.3760/cma.j.issn.1673-4912.2011.04.005
- VernacularTitle:早产儿动脉导管开放的处理
- Author:
Chao CHEN
;
Wenjing SHI
- Publication Type:Journal Article
- Keywords:
Patent ductus arteriosus;
Indomethicin;
Ibuprofen;
Preterm infant
- From:
Chinese Pediatric Emergency Medicine
2011;18(4):303-306
- CountryChina
- Language:Chinese
-
Abstract:
Patent ductus arteriosus (PDA)is a common disease among premature neonates and the management of which has always been a challenge to the neonatologists. Early treatment has been advocated as the first-line approach, and drug induced closure is yet the most effective, inexpensive, and convenient method. During the last two decades,indomethacin was often given as conservative treatment, and its closure rate in PDA was approximately 46% ～ 89%. However,indomethacin may increase the number of undesirable or harmful effects including renal damage, intraventricular hemorrhage, necrotizing enterocolitis, and enterobrosis,etc. Recently,ibuprofen is rapidly emerging as a new promising drug for treatment of PDA in preterm infants with closure rate of 73.0% ～95.5%. It is used as standard therapy to close PDA,and it has less influence on the hemodynamics of kidneys, brain and gastrointestinal tract. The surgery is needed in patients with drug treatment failure and cardio-pulmonary function damage.
