Study on abnormal expression of transforming growth factor-β1 in maternal blood and placenta of patients with fetal growth restriction

VernacularTitle:产妇血及胎盘组织转化生长因子β1异常表达与预测胎儿生长受限的研究
Author: Na LV ; Guichan WANG ; Shaojun LI
Publication Type:Journal Article
Keywords: Transforming growth factor beta1/ME; Placenta/ME; Fetal growth retardation/DI
From: Journal of Chinese Physician 2011;13(7):938-940
CountryChina
Language:Chinese
Abstract: Objective To find out the relationship between fetal growth restriction (FGR) and transforming growth factor -β1 (TGF-β1). Methods The levels of TGF-β1 in maternal serum and placental tissue of FGR were detected with using ELISA and immunohistochemistry technique, and it was compared with those of normal term pregnancy. Results The levels of TGF-β1 in maternal serum of FGR group were significantly higher than those of normal term pregnancy (76. 5 ± 33. 4 VS 47.6 ± 24. 2, t' = 4. 65, P ＜0. 05). As for the intensity of the immunohistochemistry signal, TGF-β1 in syncytiotrophoblastic cells of FGR was markedly higher than that of control group (81.82% vs 5.83%, P ＜0. 01). Conclusions The levels of TGF-β1 are closely related with FGR.