Detection of osteopontin and interleukin-18 in patients with bullous pemphigoid

VernacularTitle:大疱性类天疱疮患者骨桥蛋白和白介素18的检测
Author: Hong CHEN ; Huijuan ZHAO ; Jianlong MEN ; Qiuhong YAN ; Xiaolei CHENG ; Aidi BIN
Publication Type:Journal Article
Keywords: Pemphigoid,bullous; Osteopontin; Inerleukin-18
From: Chinese Journal of Dermatology 2012;45(9):659-661
CountryChina
Language:Chinese
Abstract: Objective To detect the expressions of osteopontin (OPN) and inerleukin-18 in patients with bullous pemphigoid (BP),and to analyze their relationship with clinical and laboratory indices.Methods Enzyme linked immunosorbent assay (ELISA) was performed to quantify the serum levels of osteopontin (OPN) and inerleukin (IL)-18 in 30 patients with BP and 30 health controls.Results The serum level of OPN was statistically higher in the patients than in the healthy controls ((8.29 ± 2.76) vs.(3.88 ± 1.41 ) ng/ml,P ＜ 0.01 ),and was positively correlated with the severity of BP (r =0.658,P ＜ 0.01 ) and with some laboratory indices in the patients.Increased serum IL-18 level was observed in patients complicated by cardiovascular diseases compared with those without cardiovascular diseases ((37.49 ± 6.43) vs.(31.10 ± 5.40) pg/ml,P ＜ 0.01).Moreover,the BP patients with diabetes,tumor,hepatic and renal impairment displayed an enhanced level of serum OPN and IL-18 than those without (all P ＜ 0.05).Conclusions OPN may be positively correlated with the severity of BP,while IL-18 may be involved in the development of complications of BP.