Drug-induced liver injury,drug disposition and metabolite profiling
10.3867/j.issn.1000-3002.2012.04.001
- VernacularTitle:药物导致肝损伤、药物处置及其代谢产物分析
- Author:
Tang WEI
- Publication Type:Journal Article
- Keywords:
liver injury;
pharmacokinetics;
metabolite analysis
- From:
Chinese Journal of Pharmacology and Toxicology
2012;26(4):467-475
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced liver injury (DILI) is a leading cause responsible for the failure of drug development and for the withdrawal of commercial drug products.The high frequency of DILI is due in part to the physiology of the liver,since in many cases elimination of drug molecules from the body is dependent on hepatic clearance via either metabolism or biliary excretion.Many of the mechanistic details underlying DILI remain poorly defined in spite of extensive studies of the pathogenesis.In this regard,metabolomics may become a powerful tool for investigation of DILI,leading to better mechanistic understanding and biomarkers identification.
