Perturbation of the transforming growth factor β system in Turner syndrome

VernacularTitle:特纳综合征患者血清转化生长因子β的变化
Publication Type:Journal Article
Keywords: Turner syndrome; Transforming growth factor beta; Cardiovascular diseases; X chromosome; Aorta
From: Journal of Peking University(Health Sciences) 2012;44(5):720-724
CountryChina
Language:Chinese
Abstract: Objective:To measure components of the circulating transforming growth factor β (TGFβ)system in patients with Turner syndrome (TS) compared to relevant controls and to ascertain correlation with endocrine and cardiovascular parameters.Methods:TGFβ1,TGFβ2 and endoglin (a vascular TGF receptor component) were measured using enzyme-linked immunoassays in the sera of 40 subjects with TS and 40 healthy volunteer women.The cardiovascular phenotype in TS subjects was extensively characterized by cardiac magnetic resonance (MR) and echo.Results:TGFβ1 levels were about 3-fold higher in TS while TGFβ2 levels were about 3.5-fold higher in controls (P ＜0.000 1 for both).Soluble endoglin levels were 25％ higher in TS (P ＜0.000 1 ).Variation in TGFβ system components was not explained by age,blood pressure,platelet count,thyroid function,body proportions or cardiovascular phenotype.Conclusion:There is profound perturbation of the TGFβ system evident in the circulation of individuals with TS.