Efficacy of metformin in the treatment of polycystic ovary syndrome in adolescents
10.3760/cma.j.issn.1000-6699.2012.08.007
- VernacularTitle:二甲双胍治疗青春期多囊卵巢综合征患者的疗效研究
- Author:
Jingjing XU
;
Yun ZHAO
;
Jinfang LIN
- Publication Type:Journal Article
- Keywords:
Adolescence;
Polycystic ovary syndrome;
Insulin resistance,Metformin
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(8):631-634
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of metformin in treating adolescent polycysfic ovary syndrome (PCOS).Methods Group A [ the metformin and medroxyprogesterone acetate (MPA) group ] was made of 135 adolescents with PCOS taking metformin,and MPA if no menstruation came,while group B ( the control group) consisted of 45 patients taking MPA every two months.Endocrinologic profiles and ovulation were evaluated before and after six months treatment.Results ( 1 ) All patients suffered from anovulation before treatment.( 2 ) Ovulation failure was successfully improved in 74.81％ ( 101/135 )of patients in group A after 6 months,which was significantly higher than that before treatment.In group B,no case recovered ovulation.(3) In group A,fasting serum insulin,homeostasis model assay for insulin resistance ( HOMA-IR),total testosterone,LH were significantly decreased.(4) The retrieval of ovulation was negatively correlated with fasting insulin and HOMA-IR ( both P＜0.05 ). Conclusions ( 1 ) Metformin effectively improves ovulation function and reproductive endocrine parameters in adolescent girls withPCOS.(2) Recovery of ovulation is associated with the decrease of serum insulin.
