Analysis of insulin release pattern in patients with polycystic ovary syndrome and normal glucose tolerance
10.3760/cma.j.issn.1000-6699.2012.08.008
- VernacularTitle:正常葡萄糖耐量多囊卵巢综合征患者胰岛素释放试验分析
- Author:
Xuezhen LUO
;
Yingjue CHEN
;
Wen XU
;
Mingwei ZHU
;
Jinfang LIN
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Oral glucose tolerance test;
Insulin release test;
Insulin resistance;
Area under curve
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(8):635-637
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the release pattern of insulin after the load of glucose in patients with polycystic ovary syndrome ( PCOS ) and normal oral glucose tolerance.Methods Sixty-three patients with PCOS were undertaken oral glucose tolerance test (OGTT) and insulin release test,while 34 women with normal menstrual cycle served as control.Results Among 63 patients with PCOS,33 cases were obese with body mass index over 25 kg/m2,including 5 with abnormal OGTT.All 30 non-obese patients with PCOS had normal OGTT.The prevalences of insulin resistance were 78.8％,16.7％,and 9.0％ in obese PCOS,non-obese PCOS,and control groups,respectively.Abnormal insulin release curve were found in 84.5％,70.0％,and 14.7％ of subjects in these 3 groups,respectively.In 58 PCOS patients with normal OGTT,the prevalence of insulin resistance was 44.8％,and 75.9％with abnormal insulin release curve. Among them,body mass index of 32 patients,whose homeostasis model assessment for insulin resistance (HOMA-IR) and fasting insulin remained in normal range,was similar to those of control group [ ( 20.52 ± 2.86 vs 20.01 ± 2.54 ) kg/m2,P＞0.05].Conclusion These findings indicate that insulin release test is useful in detecting insulin resistance.Insulin release is elevated in PCOS patients even with normal OGTT.
