Efficacy and safety of tolterodine on late-onset overactive bladder symptoms after prostate brachytherapy
10.3760/cma.j.issn.1000-6702.2012.09.007
- VernacularTitle:托特罗定治疗前列腺癌粒子植入术后迟发性膀胱过度活动症的疗效及安全性
- Author:
Yanjun ZHU
;
Zhibing XU
;
Guomin WANG
;
Yeqing XU
;
Jianming GUO
- Publication Type:Journal Article
- Keywords:
Overactive bladder;
Prostatic neoplasms;
Carcinoma;
Brachytherapy
- From:Chinese Journal of Urology
2012;33(9):660-663
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy and safety of tolterodine on late-onset overactive bladder symptoms after prostate brachytherapy due to prostate carcinoma.Methods Twenty-six prostate cancer patients diagnosed by biopsy,who underwent prostate brachytherapy using iodine-125,were recrui(t)ed in this trial.All cascs complained of overactive bladder symptoms 6 months postoperatively.The 26 patients were divided into 2 groups:14 men in tolterodine group (TR group) who were given tolterodine 2 mg twice a day; 12 men in tamsulosin group (TS group) who were given tamsulosin 0.2 mg once a day.Efficacy was assessed by changes in IPSS,OABSS and nighttime voiding at 2 weeks and 4 weeks after medical treatment respectively.Safety was assessed by postvoid residual (PVR) and acute urinary retention (AUR),dry mouth,constipation and tachycardia at the fourth week after medical treatment.Results The age,tumor staging,GS,PSA,initial prostate volume,IPSS,OABSS,nighttime voiding,iodine-125 seeds implanted and needles punctured of both groups were comparable.IPSS,OABSS and nighttime voiding were significantly improved in TR group after 2 weeks of medical treatment and the above parameters were significantly improved than TS group (14.4 vs 18.3,5.9 vs8.4,1.4 vs2.5).OAB symptoms of TR group were also significantly improved than TS group after 4 weeks of therapy.There were no significant differences of PVR and AUR,dry mouth,constipation and tachycardia between both groups.Conclusions Tolterodine is effective and safe in treating late-onset OAB symptoms after prostate brachytherapy,although the occurence of dry mouth and tachycardia might be increased.
