Similar Neutralizing Activity in the HIV-1 Infected Long Term Non-progressors(LTNPs) and Typical Progressors(TPs)
10.1007/s12250-012-3239-8
- Author:
Zheng WANG
;
Tianyi LI
;
Jingyun LI
;
Lili CHEN
;
Yongjian LIU
;
Hanping LI
;
Zuoyi BAO
;
Xiaolin WANG
;
Daomin ZHUANG
;
Siyang LIU
;
Lin LI
- Publication Type:Journal Article
- Keywords:
HIV-1;
Long term non-progressor(LTNP);
Typical progressor(TP);
Neutralization activity
- From:
Virologica Sinica
2012;27(3):165-171
- CountryChina
- Language:Chinese
-
Abstract:
Neutralizing antibodies are considered to be an important protective parameter used in HIV-l vaccine evaluation.However,the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined.In this paper,we compared the protective function of the neutralizing antibody response in the plasma from LTNP and TP against clade B and clade C pseudoviruses.No difference in the neutralizing activities between the plasma from LTNP and TP was found,which was consistent with the most recent reports.In addition,no correlations between the titer or breadth and CD4+ or viral load in HIV-1 infected individuals were found.The protective roles played by neutralizing antibodies in controlling disease progression of HIV-1 infected people need to be considered in a new viewpoint.
