Immunohistochemical and ultrastructural study on the invasive cervical carcinoma
- Author:
Huong Thuy Nguyen
- Publication Type:Journal Article
- Keywords:
cervical cancer
- MeSH:
Carcinoma;
Uterine Cervical Neoplasms;
ultrastructure
- From:Journal of Vietnamese Medicine
2002;277(10):6-9
- CountryViet Nam
- Language:Vietnamese
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Abstract:
The aim of this study is to identify some immunohistochemical, and ultrastructural characteristics of invasive cervical cancer (ICC). Twenty seven cases were immunohistochemically examined for the presence of cytokeratin AE1/AE3, Her-2/neu, CD20 and CD45. Ultrastructural study was carried out on 10 cases. Results: Immunohistochemical stains for AE1/AE3 were positive in 92.29% of cases and very helpful in the identification of tumor cell differentiation. The majority of infiltrating lymphocytes was T-cells. Her 2/neu oncogene expression was high. Ultrastructurally, the cells showed a scantly cytoplasm, decrease of cytoplasmic organelles, decrease of intercellular adhesion and apparition of microvillosities in adenocarcinoma. The presence of HPV virus-like particles was found in two cases. The crystals were revealed in the eosinophilic leukocyte granules.
