Systemic and cellular responses to intermittent hypoxia relevance to recurrent apnea syndrome
10.3969/j.issn.1672-8467.2012.01.001
- VernacularTitle:机体和细胞对间歇性低氧的反应与呼吸暂停综合征的关系
- Author:
R.prabhakar NANDURI
- Publication Type:Journal Article
- Keywords:
intermittent hypoxia;
recurrent apnea syndrome;
cellular mechanism
- From:
Fudan University Journal of Medical Sciences
2012;39(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Patients with sleep-disordered breathing with recurrent apneas exhibit autonomic dysfunction including elevated sympathetic nerve activity (SNA) and hypertension.Studies on experimental animals show that chronic intermittent hypoxia (CIH) resulting from recurrent apneas is a major stimulus for evoking autonomic dysfunction.In rodent models,CIH enhances arterial chemoreflex function in part due to enhanced carotid body sensitivity to hypoxia.The enhanced chemo-reflex leads to elevated sympathetic nerve activity.Recent studies suggest that transcriptional changes involving hypoxiainducible factor-1 and 2 (HIF-1,HIF-2) and the resulting reactive oxygen species-mediated signaling are critical cellular mechanisms underlying the chemoreflex-mediated excitation of sympathetic nervous system by CIH.
