Antioxidization and antiproliferation of extract from leaves of Toona sinensis
10.3969/j.issn.1672-7347.2012.01.008
- VernacularTitle:香椿叶提取物抗氧化和抑制癌细胞增殖的研究
- Author:
Jinfu LIU
;
Lingling YOU
;
Changlu WANG
;
Ruihai LIU
- Publication Type:Journal Article
- Keywords:
Toona sinensis;
phenolics;
antioxidant;
antiproliferation;
cancer
- From:
Journal of Central South University(Medical Sciences)
2012;37(1):42-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the antioxidization and antiproliferation of extract from leaves of Toona sinensis (LTS).Methods:The total phenolic extract of LTS was obtained by solvent and polyamide resin to determine the content.The antioxidization of the LTS extract was measured by TOSC assay.Antiproliferation was studied in vitro with different human cancer cells.Results:The total phenolic content in the LTS was (427.53±4.31) mg/g and antioxidization was 807.64 μmoL vitamin C equivalents/g in the sample.The extract significantly inhibited the colon cancer cell Caco-2,human liver cancer cell HepG2 and breast cancer cell MCF-7 proliferation with EC50 (4.00±0.39),(153.16±13.49) and (193.46±14.68) μg/mL,respectively.The bioactivity index (BI) of the LTS extract was nearly 283.Caco-2 was more sensitive than MCF-7 and HepG2.Conclusion:Extract from LTS has anticancer properties useful for preventing chronic diseases.
