Relevance of lipoprotein ( a ) and atherosclerotic renal artery stenosis: a Meta-analysis of observational studies

VernacularTitle:脂蛋白a与动脉粥样硬化性肾动脉狭窄发病关联的Meta分析
Author: Peng XIA ; Lanping JIANG ; Limeng CHEN ; Xuemei LI
Publication Type:Journal Article
Keywords: Lipoprotein (a); Atherosclerotic renal artery stenosis; Meta analysis
From: Chinese Journal of Clinical Nutrition 2012;20(1):1-5
CountryChina
Language:Chinese
Abstract: Objective To explore the relevance between lipoprotein(a) and atherosclerotic renal artery stenosis in adults.Methods Literature search was conducted in PubMed and EMBASE Database,using “atherosclerotic renal artery stenosis” as the search term as well as in Wanfang Database,China National Knowledge Infrastructure,and Cqvip Database,using “renal artery stenosis” and “lipoprotein” as the search terms,aiming to find case-control or cohort studies published before 2010.The qualities of all the literatures enrolled were evaluated using Newcastle-Ottawa scale and the data from which were analyzed by the Review Manager 5.0 software.Results Five eligible case-control studies (661 cases) entered the Meta analysis.The results showed that the lipoprotein(a) level was not significantly higher in the case group than that in the control group [ mean difference =0.0702 g/L,95％ CI ( - 0.0688,0.2092),P =0.32 ].Conclusion According to the existing studies,the relevance between lipoprotein(a) and atherosclerotic renal artery stenosis can not be established.