Serum leptin and ghrelin levels in patients with active ulcerative colitis
10.3760/cma.j.issn.1674-635X.2012.01.003
- VernacularTitle:活动期溃疡性结肠炎患者血清瘦素与ghrelin水平的临床分析
- Author:
Shuang ZHANG
;
Qiao MEI
;
Jianming XU
;
Xu ZHANG
;
Qingfeng YANG
;
Liping ZHANG
;
Yong JIANG
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Leptin;
Ghrelin;
Inflammatory bowel disease
- From:
Chinese Journal of Clinical Nutrition
2012;20(1):10-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of serum leptin and ghrelin levels in patients with active ulcerative colitis (UC) and their clinical significance.Methods Fifty-four patients with active UC and 25 normal controls were enrolled in this study,and serum levels of leptin and ghrelin were determined by enzyme-linked immunosorbent absorption.The correlations between serum leptin/ghrelin and the main clinicopathological features of patients with active UC were analyzed.The nutritional status of these patients were assessed by using the Nutritional Risk Screening 2002 ( NRS 2002).Results The serum levels of leptin and ghrelin in patients with active UC were significantly higher than those in normal controls [leptin:(245.51 ± 129.72) vs.( 183.80 ±59.67) pg/ml,P =0.029; ghrelin:(1477.96 ±501.86) vs.(1188.00±474.51) pg/ml,P=0.041]; and both of them were correlated with the disease severity ( leptin:r =0.715,P =0.019 ; ghrelin:r =0.667,P =0.027),but were not correlated with the clinical type,the extent of lesion,and the endoscopic grading (all P ＞ 0.05).In the UC patients with nutritional risk,the serum levels of leptin and ghrelin were also significantly higher than those in subjects without nutritional risk [ leptin:(332.82 ± 172.92) vs.( 194.15 ± 49.71 ) pg/ml,P =0.026 ; ghrelin: ( 1848.60 ±326.48) vs.(1259.93±459.24) pg/ml,P=0.021].Conclusion Patients with active UC have remarkably higher serum leptin and ghrelin levels,which is associated with the disease severity and the nutritional risk.
