Coagulation disorders are associated with severity of sepsis in infected patients admitted toemergency department
10.3760/cma.j.issn.1671-0282.2012.02.003
- VernacularTitle:急诊感染患者凝血障碍与脓毒症严重程度的关系
- Author:
Wei ZHANG
;
Zhaofeng LIN
;
Jinlong QU
;
Liang CHANG
- Publication Type:Journal Article
- Keywords:
Infection;
Sepsis;
Severe sepsis;
Platelets;
D-dimer;
PT;
INR;
Thromboelastography;
MA value
- From:
Chinese Journal of Emergency Medicine
2012;21(2):123-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between coagulation disorders and sepsis severity of infected patients.Methods In this retrospective study,75 patients,51 males,24 femalse,with age(55.8± 18.1),were included from January 2010 to March 2011.They were clinically diagnozed as infection,and had Thromboelastography(TEG)and routine coagulation test within 24 hours after admission to emergency department.They were divided into 3 groups based on SIRS and SOFA score within 24 hours after admission:a)infection group,patients without SIRS; b)sepsis group,patients with SIRS and SOFA score less than 5; c)severe sepsis group,patients with SOFA score greater than or equal to 5.LSD was used to compare between two groups if one-way ANOVA of three groups comparasion showed significant differences.Results In comparasion to sepsis group(n =29)and infection group(n =27),D-dimer elevated significantly in severe sepsis group(n =19)(F =3.388,P =0.004),and platelet count decreased significantly(F =3.839,P =0.026),INR and KPTT showed an increase trend without significant difference (F =2.657,P =0.077 ; F =2.782,P =0.069); TEG showed MA obviously decreased(F =5.841,P =0.004),while there were nostatistically significant differences among other data.Conclusions The extent of coagulation disorders and sepsis severity of infected patients is closely correlated to each other.
