Effect of donor GFR on early renal function of recipients with living donor transplantation
10.3760/cma.j.issn.1001-7097.2012.09.004
- VernacularTitle:活体肾移植供肾肾小球滤过率对受体早期肾功能的影响
- Author:
Jingcai HOU
;
Jiguang FEI
;
Changxi WANG
;
Suxiong DENG
;
Gang HUANG
;
Dongwei LI
;
Jun LI
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Glomerular filtration rate;
Creatinine
- From:
Chinese Journal of Nephrology
2012;28(9):679-682
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of donor GFR on the early renal function in recipients undergoing living donor transplantation.Methods A total of 172 living donor transplant recipients in our kidney transplantation center from 2006 to 2011 were enrolled into this study.Among them,166 were genetically related (96.5％),while 6 were genetically unrelated (spouses in 5 and other in 1).The predonation GFR was measured by isotope clearance (99mTC-DTPA with few exceptions).The range of donor GFR was 62 to 148 ml/min.The recipients were classified into two groups according to donor graft GFR level (GFR≤45 ml/min,n=76; GFR＞45 ml/min,n =96).The predonation dialysis,cold and warm ischemia time,antibody induction,immunosuppressive regimens and HLA mismatch were not significantly different between two groups.Results There were no significant differences in the incidence of postoperative acute rejection and delay graft function (DGF).The postoperative Scr of GFR＞45 ml/min group in 1 week,1 month,3 months and 1 year was lower compared with the GFR ≤45 ml/min group,and only the difference of Scr in 1 week was significantly different (P＜0.05).A repeated-measure ANOVA revealed no significant differences were found in Scr variation of two groups during the first year after transplantation.Conclusions Predonation GFR of the donor has effect on the Scr of postoperative Ⅰ week of recipients,not on the Scr within a year.Recipients with graft GFR＞45 ml/min have lower Scr levels.
