Value of plasma ADMA in predicting cardiac structure and function of patients with chronic kidney diseases
10.3760/cma.j.issn.1001-7097.2012.09.005
- VernacularTitle:血浆不对称二甲基精氨酸对慢性肾脏病患者心脏结构及功能的预测价值
- Author:
Jianhua YE
;
Xiaoling ZHOU
;
Menghua CHEN
- Publication Type:Journal Article
- Keywords:
Kidney diseases,chronic;
Cardiovascular diseases;
Asymmetric dimethylarginine
- From:
Chinese Journal of Nephrology
2012;28(9):683-686
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predicting value of plasma asymmetric dimethylarginine (ADMA) in cardiac structure and function of patients with chronic kidney diseases (CKD).Methods A total of 100 CKD patients were enrolled in this cross-sectional study.According to staging of the K-DOQI guideline,CKD patients were divided into five groups.Twenty healthy people were enrolled as control.Plasma level of ADMA was determined by reversed-phase high performance liquid chromatography.Cardiac structure and function were detected by color echocardiography.Results Plasma levels (μmol/L) of ADMA in CKD stage 3 to 5 patients (1.3318±0.4684,1.5712±0.4210,2.1093±0.7714) were significantly higher than those in CKD stage 1,2 patients (0.4387±0.2575,0.4809±0.2846) and healthy control (0.4611±0.1615) (all P＜ 0.01).Meanwhile,ADMA level of CKD stage 5 was significantly higher as compared to CKD stage 3-4.The left ventricular mass index (LVMI) was significantly higher in stage 4-5 patients than that in stage 1-3 and healthy control.Plasma ADMA was positively correlated with LVMI (r=0.476,P=0.028) and negatively correlated with left ventricular ejection fraction (EF) (r=-0.327,P=0.041).Multivariate stepwise Logistic regression analysis revealed plasma ADMA level was an independent predictors for EF (OR=0.984,P＜0.01).Conclusions Plasma level of ADMA begins to increase in CKD patients of stage 3 and rises proportionally to the decline of renal function.Plasma ADMA level is useful in predicting the cardiovascular complications of CKD patients.
