Modulation of cardiac fibroblast function by thiazolidinediones with a focus on the role of LOX-1
10.3969/j.issn.1672-7347.2011.10.003
- VernacularTitle:噻唑烷二酮类胰岛素增敏药和LOX-1对心脏成纤维细胞功能的调节作用
- Publication Type:Journal Article
- Keywords:
cardiac fibroblast;
thiozolidinediones;
lectin-like oxidized low-density lipoprotein receptor-1;
peroxisome proliferator-activated receptor γ
- From:
Journal of Central South University(Medical Sciences)
2011;36(10):939-948
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac fibroblasts play a pivotal role in cardiac remodeling.In response to various pro-fibrotic stimuli,such as pro-inflammatory cytokines,anoxia-reoxygenation and pressure overload as well as aging,cardiac fibroblasts undergo proliferation,migration and activation,leading to the accumulation of extracellular matrix components and increased thickness and stiffness of heart.The ligands for peroxisome proliferator-activated receptor γ,especially thiazolidinediones,modulate the function of cardiac fibroblasts and the progression of cardiac remodeling,especially under pathological conditions.Unfortunately these agents have not been found to be consistently beneficial in heart failure.Although the precise intracellular signaling pathways are not fully understood,existing evidence strongly supports the involvement of oxidative stress and related signaling pathways.Further,peroxisome proliferator-activated receptor γ and lectin-like oxidized low-density lipoprotein receptor-1 together play critical roles in thiazolidinediones-modulated cardiac fibroblast dysfunction.
