(2009ZC116M).Relationship of biomaterials related infections and transforming growth factor levels in the peripheral blood of lung cancer patients
10.3969/j.issn.1673-8225.2011.47.042
- VernacularTitle:肺癌患者生物材料相关感染与外周血转化生长因子β1水平的关系
- Author:
Yujie LEI
;
Yunchao HUANG
;
Li YANG
;
Fengli GUO
;
Guangqiang ZHAO
;
Yushan XU
;
Xiaobo CHEN
;
Kaiyun YANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2011;15(47):8907-8910
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Permanent or transient implantation of biomaterials can result in biomaterials-centered infections (BCI) in lung cancer patients.OBJECTIVE: To investigate the relationship between BCI and peripheral blood transforming growth factor β1 (TGF-β1) in patients with lung cancer.METHODS: A total of 248 lung cancer patients undergoing in vivo intravascular catheter indwelling > 7 days were included.Quantitative method was used for intubation, bacteriological culture and paired blood culture, and API Staph strips were adopted for positive patients. While enzyme-linked immunosorbent assay was used to detect TGF-β1 levels in the peripheral blood of patients with lung cancer and 75 healthy volunteers as normal controls.RESULTS AND CONCLUSION: Among the 248 patients, there were 82 BCI-positive cases, and 166 BCI-negative cases.Thirteen patients were confirmed to have catheter-related bloodstream infection. There were 48 Gram-positive bacteria, 24Gram-negative bacilli, and 10 fungal. The levels of TGF-β1 were higher in BCI-positive patients than BCI-negative patients (P < 0.05); the levels of TGF-β1 in the BCI-negative group were higher than those in the normal control group (P < 0.05). For lung cancer patients with nosocomial infection induced BCI, there are various species of pathogenic bacteria, and Gram-positive bacteria are more common. To detect TGF-β1 levels in patients with lung cancer is of significance for early prevention of BCI.
