Preparation and properties of porous co-substituted calcium polyphosphate scaffold as bone repair material*
10.3969/j.issn.1673-8225.2011.38.004
- VernacularTitle:多孔复合掺杂聚磷酸钙支架骨修复材料的制备及其性能
- Author:
Qifei JING
;
Xu ZHANG
;
Huixu XIE
;
Qiguang WANG
;
Xiaohua ZHANG
;
Xixun YU
;
Changxiu WAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2011;15(38):7045-7048
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Ions doping is an important method for the modification of bioceramic.OBJECTIVE: To evaluate a novel co-substituted bioceramic scaffolds as bone repair material.METHODS: The microstructure and crystallization of the scaffolds were detected by scanning electron microscope and X-ray diffraction. Compression strength test,degradation test and cell culture experiment were assumed to evaluate the properties of KSCPP in vitro. After a short period of muscle pouches implantation,the performance of KSCPP in vivo was evaluated.RESULTS AND CONCLUSION: The results show that KSCPP scaffold has a higher compressive strength and degradation rate. Moreover,the MTT assay and implantation test reveal that the KSCPP scaffold exhibits lower cytotoxicity and better tissue biocompatibility than CPP and HA. The study proved the great potential of KSCPP in bone repair applications.
