Local application of ibandronate enhances early fixation of implants X-ray, histomorphology and biomechanical pull-out tests
10.3969/j.issn.1673-8225.2011.35.002
- VernacularTitle:局部应用伊班膦酸钠能加强内植物的早期固定:经X射线、组织学及生物力学结果验证
- Author:
Qiudong LU
;
Wenhai HU
;
Chengli LI
;
Tongyu HU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2011;15(35):6466-6470
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: The aseptic loosening of prosthesis has become one of the most obvious matters after operation of prosthesis replacement. OBJECTIVE: To verify the effect of ibandronate on early fixation of implants by local application. METHODS: Forty-four Zelanian rabbits were used in the experiment. A standard animal model of the rabbits' both tibia was embedded with metal screw into the proximal end. Ibandronate at 1 mg/L was sprinkled locally in the left tibia of every rabbit (experimental group), while saline solution was given in the right tibia (control group). (P < 0.001). These findings indicate that, local application of ibandronate solution can obviously promote new bone formation at the earlier period, improve early fixation of implants and decrease the incidence of aseptic loosening of prosthesis.
