Correlation of Decreased Expressions of Claudin 4 and E-cadherin Proteins and the Clinicopathologic Factors of Stomach Cancer.
- Author:
Sung Min LEE
1
;
Jung Hyo LEE
;
Beom Gyu KIM
;
Yong Seok KIM
;
Yong Gum PARK
;
Kyung Chun CHI
;
Hyun Muk LIM
;
Sang Jun KIM
Author Information
1. Department of Surgery, Chung-Ang University College of Medicine, Seoul, Korea. minjuna@korea.com
- Publication Type:Original Article
- Keywords:
Stomach cancer;
Claudin-4;
E-cadherin
- MeSH:
Adenocarcinoma;
Cadherins*;
Claudin-4*;
Neoplasm Metastasis;
Stomach Neoplasms*;
Stomach*
- From:Journal of the Korean Surgical Society
2007;73(3):221-226
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We examined the expressions of claudin-4 and E-cadherin, which are known as cell adhesion-associated proteins, in stomach cancer. The relationship of their expression with the clinicopathologic factors was examined to investigate the roles of these proteins in the invasion or metastasis of stomach adenocarcinoma. METHODS: The expressions of claudin-4 and E-cadherin were examined in 73 cases of adenocarcinoma of the stomach by performing immunohistochemical staining. RESULTS: The expressions of claudin-4 and E-cadherin in the stomach adenocarcinoma were both correlated with the histologic grade, the T-stage and nodal metastasis, respectively (P<0.05). The expression of claudin-4 was significantly associated with the expression of E-cadherin. CONCLUSION: Our data suggests that claudin-4 and E-cadherin are involved in the processes of histologic differentiation, invasion and metastasis of stomach adenocarcinoma.
