Aggravation of electroencephalographic features in an epileptic child treated by oxcarbazepine monotherapy: A case report and review of the literature

VernacularTitle:奥卡西平治疗儿童癫痫导致脑电图恶化1例报告并文献分析
Author: Fang YANG ; Ling LIU ; Qian LI ; Jiafei DAI ; Maowei CHENG ; Li KONG ; Shenning ZHANG ; Guanghui CHEN
Publication Type:Journal Article
Keywords: Seizure; Oxcarbazepine; Electroencephalograghy
From: Journal of Medical Postgraduates 2011;24(5):495-498
CountryChina
Language:Chinese
Abstract: Objective Benign childhood epilepsy with centrotemporal spikes (BECT) is the most common partial epilepsy syndrome in children, and responds well to carbamazepine (CBZ), oxcarbazepine (OXC), and valproic acid (VPA). The aim of this study is to investigate the therapeutic effect of OXC on BECT. Methods We retrospectively discussed a case of partial epilepsy in a 6-year-old boy with no abnormality on neuroradiologic examination. Results The patient′s seizures were easily controlled by administration of OXC, but electroencephalography (EEG) identified deterioration of the EEG features following the introduction of OXC monotherapy. Then OXC was gradually decreased in dose and substituted with VPA. When VPA was increased to the dose of 0.5g/d, the boy had no more seizures and exhibited normal EEG in the conscious state. Conclusion OXC may induce new types of seizure and aggravate EEG features although it is considered to be the first-line anti-epileptic drug (AED) and much better tolerated than either phenytoin or CBZ.