Preemptive analgesia effect of parecoxib sodium in patients with cervical carcinoma undergoing radical resection under laparoscopy
- VernacularTitle:帕瑞昔布钠在腹腔镜下宫颈癌根治术镇痛中的应用
- Author:
La WEI
;
Fufen MENG
;
Feng YANG
- Publication Type:Journal Article
- Keywords:
Parecoxib sodium;
Analgesia;
Cervical cancer;
Morphine
- From:
The Journal of Clinical Anesthesiology
2010;(12):1037-1039
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the preemptive analgesia effect of parecoxib sodium in patients undergoing laparoscopic cervical carcinoma radical resection.Methods Seventy patients undergoing laparoscopic cervical carcinoma radical resection were randomly divided into 2 groups with 35 cases each. Parecoxib sodium 40 mg was injected intravenously 10 min before operation and repeatedly given every 12 h. Equal volume physiological saline was given at same time in the control group. Two groups received postoperative PCIA with morphine. The numerical rating scale （NRS） was used to rate pain intensity at following time points：immediately after extubation,2,6,12,18,and 24 h after operation. Twenty-four hour morphine consumption and side effects were recorded.Results The NRS rating of pain at each time point in the parecoxib group was significantly lower than that of the control group （P0.05）,and the total morphine consumption （10.4±7.6）mg was less than the control （17.7±8.9）mg （P0.05）; correspondingly,the incidences of nausea,vomiting and drowsiness were less,and the number of patients left bed for activity was increased in the parecoxib group than those in the control one （P0.05）. Conclusion Preoperative parecoxib sodium 40 mg can improve the analgesic effect of PCIA with morphine,and reduce morphine consumption and the incidences of side effects.
