Research progress of histone deacetylase inhibitors in the theraphy of anti-sepsis shock in animal experiments
10.3760/cma.j.issn.1673-4203.2012.11.015
- VernacularTitle:组蛋白去乙酰化酶抑制剂抗感染性休克治疗动物实验的研究进展
- Author:
Xiaohua GAO
;
Zhilong GENG
- Publication Type:Journal Article
- Keywords:
Histone deacetylase inhibitors;
Shock;
At the molecular level;
Fluid resuscitation;
Animal experimentation
- From:
International Journal of Surgery
2012;39(11):770-773
- CountryChina
- Language:Chinese
-
Abstract:
It has demonstrated histone deacetylase inhibitor to be protective in preclinical and early clinical studies for the therapy of cancer,central nervous system degenerative diseases and immune system diseases.Strikingly,Recent studies have shown that it has emerged as a potent prosurvival and anti-inflammatory drug,offering new lines of therapeutic intervention for sepsis shock,and can reverse the changes of genes expression at the molecular level,caused by sepsis shock and its follow-up of fluid resuscitation.What' s more,it has slight impact on hemodynamics,ultimately alleviates lesions to systemic inflammatory response syndrome and multiple organ failure syndrome and simultaneously lays a good foundation to win the golden time for treatment.On the other hand,with the development of second hit theory,it will also set up a bridge between hemorrhagic shock and septic shock,resulting in expansioning the breadth and depth of understanding of shock.In brief,histone deacetylase inhibitors are the extension and challenges of the traditional therapy of anti-sepsis shock.
