Evaluation of combination therapy with tolterodine and tamsulosin for the treatment of the double J stent-related symptoms
10.3760/cma.j.issn.1000-6702.2012.09.017
- VernacularTitle:托特罗定联合坦索罗辛治疗双J管置入后相关症状的临床观察
- Author:
Zhiqiang ZHANG
;
Dexin YU
;
Dongdong XIE
;
Xiaoli SU
;
Haoqiang SHI
;
Yi WANG
;
Tao ZHANG
;
Demao DING
;
Jie MIN
;
Han CHU
- Publication Type:Journal Article
- Keywords:
Toltcrodin;
Tamsulosin;
Overactive bladder symptoms;
Ureteral stent
- From:
Chinese Journal of Urology
2012;33(9):692-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of combination therapy of tolterodine and tamsulosin in improving symptoms in patients with indwelling double-J ureteral stents.Methods A total of 96 patients underwent placement of a double-J ureteral stent after retrograde ureteroscopy for urinary stone disease,which were prospectively randomized ( random numbers table) into two groups.The tamsulosin group ( n =48) was administered tamsulosin 0.2 mg once daily,the combination group (n =48) was administcred tamsulosin 0.2 mg once daily and tolterodine 2 mg twice daily.All the patients completed a validated Ureteral Stent Symptom Questionnaire (USSQ),the Overactive Bladder Symptom Score (OABSS),the International Prostate Symptom Score (IPSS) one day before he placement and 4 weeks after stent placement of stent.Results The mean urinary symptom index score (25.4 ± 4.0 vs 15.3 ± 2.9,P ＜ 0.0001 ),the mean pain index score (15.0 ±2.6 vs10.3 ±2.1,P ＜0.0001),the mean general health index score (15.4 ±2.2 vs 11.0±1.5,P＜0.0001),the work performance index score (13.0±2.2vs9.7±1.9,P＜0.0001),the sex index score (3.6 ± 1.1 vs 2.2 ± 0.9,P ＜0.0001 ) improved significantly in combination group than those in tamsulosin group.There was a statistically significant difference between tamsulosin group and combination group in the IPSS score ( 12.8 ± 2.0 vs 9.2 ± 1.7,P ＜ 0.0001 ) and OABSS score ( 6.7 ± 1.4 vs 4.2 ± 1.4,P ＜ 0.0001 ) at the 4 weekfollow-up.Conclusions Indwelling ureteral stents have a significant impact on health related quality of life.It is effective for improving symptoms in patients with indwelling double-J ureteral stents by combination therapy with tolterodine and tamsulosin.
